Large Scale Production of Perturbagen-Induced Cellular Signatures (U54)

Post Date

February 26th 2010

Application Due Date

April 27th 2010

Funding Opportunity Number

RFA-RM-10-003

CFDA Number(s)

93.310

Funding Instrument Type(s)

Cooperative Agreement

Funding Activity Categories

Health

Eligibility Categories

State Governments
County Governments
City or Township Governments
Special District Governments
Independent School Districts
Public and State Controlled Institutions of Higher Education
Federally Recognized Native American Tribal Governments
Public Housing Authorities or Indian Housing Authorities
Non-Federally Recognized Native American Tribal Organizations
Non-Profits With 501 (c) (3) Status With The IRS (Except Higher Education Institutions)
Non-Profits Without 501 (c) (3) Status With The IRS (Except Higher Education Institutions)
Private Institutions of Higher Education
For-Profit Organizations (Except Small Businesses)
Small Businesses
Other

Other Eligible Applicants include the following: Alaska Native and Native Hawaiian Serving Institutions; Eligible Agencies of the Federal Government; Hispanic-serving Institutions; Historically Black Colleges and Universities (HBCUs); Indian/Native American Tribal Governments (Other than Federally Recognized); Non-domestic (non-U.S.) Entities (Foreign Organizations); Regional Organizations; Tribally Controlled Colleges and Universities (TCCUs) ; U.S. Territory or Possession.

Funding

• Estimated Total Funding:

  $12700000

• Award Range:

  $None - $900000

Grant Description

Purpose. This FOA seeks to establish a pilot-scale data production effort to systematize approaches for identifying mechanism-based associations among the effects of disparate biological perturbations, a knowledge base that can be used to study functional relationships among the responding cellular components. The Library of Integrated Network-Based Cellular Signatures (LINCS) program will support the high-throughput collection and integrative computational analysis of informative molecular activity and cellular feature signatures generated in response to a variety of perturbing agents, including siRNAs and small bioactive molecules, which are applied to a set of carefully selected cell types. The resulting knowledge will form the basis of a long-lived resource that can be used broadly by the community. For example LINCS may inform association of disease states with detailed molecular or cellular phenotypes, and ultimately associate disease with specific gene networks, or inform the mechanism of action of known drugs. This FOA seeks to fund pilot-scale data production efforts that will produce a usable initial resource while addressing the following issues: optimization of methods, integration of data, and scalability. Pilot production efforts will interact with multiple future additional components (data analysis and informatics tools; and development and integration of new production-ready technologies) of the LINCS program. Mechanism of Support. This FOA will utilize the U54 specialized centers cooperative agreement award mechanism. It is intended to complement FOAs that will be issued in FY 2011 for development and integration of new production-ready technologies and for development of informatics and data analysis tools for LINCS. Funds Available and Anticipated Number of Awards. We expect to fund up to two awards in FY 2010. Three years of funding may be requested. Total funds available for the program are $2.7M in FY 2010, ramping to $5M in each of FY 2011 and FY 2012.

Contact Information

• Agency

  Department of Health and Human Services

• Office:

  National Institutes of Health

• Agency Contact:

  NIH OER Webmaster
  FBOWebmaster@OD.NIH.GOV
  

• Agency Mailing Address:

  If you have any problems linking to this funding announcement, please contact the NIH OER Webmaster

• Agency Email Address:

  FBOWebmaster@OD.NIH.GOV

• More Information:

  http://grants.nih.gov/grants/guide/rfa-files/RFA-RM-10-003.html