NINDS Ischemic Stroke Genetics Consortium (U01)

Post Date

February 26th 2009

Application Due Date

May 15th 2009

Funding Opportunity Number

RFA-NS-09-002

CFDA Number(s)

93.853

Funding Instrument Type(s)

Cooperative Agreement

Funding Activity Categories

Health

Number of Awards

1

Eligibility Categories

State Governments
County Governments
City or Township Governments
Special District Governments
Independent School Districts
Public and State Controlled Institutions of Higher Education
Federally Recognized Native American Tribal Governments
Public Housing Authorities or Indian Housing Authorities
Non-Federally Recognized Native American Tribal Organizations
Non-Profits With 501 (c) (3) Status With The IRS (Except Higher Education Institutions)
Non-Profits Without 501 (c) (3) Status With The IRS (Except Higher Education Institutions)
Private Institutions of Higher Education
For-Profit Organizations (Except Small Businesses)
Small Businesses
Other

Other Eligible Applicants include the following: Alaska Native and Native Hawaiian Serving Institutions; Eligible Agencies of the Federal Government; Faith-based or Community-based Organizations; Hispanic-serving Institutions; Historically Black Colleges and Universities (HBCUs); Indian/Native American Tribal Governments (Other than Federally Recognized); Non-domestic (non-U.S.) Entities (Foreign Organizations); Regional Organizations; Tribally Controlled Colleges and Universities (TCCUs) ; U.S. Territory or Possession.

Funding

• Award Range:

  $None - $900000

Grant Description

Purpose.This funding opportunity announcement (FOA) issued by the National Institute of Neurological Diseases and Stroke (NINDS), the National Institutes of Health (NIH) solicits grant applications from institutions/ organizations that propose to establish a genome-wide association study consortium focused on the goal of identifying genes that influence the risk and outcome of ischemic stroke.The NINDS will support one such multi-center consortium.This project will create a permanent global resource, via the Database of Genotype and Phenotype (dbGAP), of genotyping data of rigorously phenotyped ischemic stroke cases.The proposed study should concentrate on using existing DNA sample sets.Each application submitted in response to this FOA must include plans to establish:(i) a Data Coordinating Center (DCC) and (ii) Genetic Research Centers (GRC) that together would be able to make available a sufficient number of genotyped and uniformly phenotyped samples to provide statistical power for a meaningful GWAS analysis (6,000 or more samples is an estimate of an appropriate sample size).The Consortium should develop standardized, validated, and easily replicated methods to assign stroke subtypes for this GWAS analysis.The samples submitted for this GWAS should be accompanied by clinical data to support the endophenotyping in this study and more importantly, to enable the utilization of the data from these study in future subtype-specific studies.The goal of this announcement is not only to enable an initial exploration of genes that affect susceptibility and outcome, but also to create a national resource of high quality information for data mining, replication studies, and future hypothesis generation.

Contact Information

• Agency

  Department of Health and Human Services

• Office:

  National Institutes of Health

• Agency Contact:

  NIH OER Webmaster
  FBOWebmaster@OD.NIH.GOV
  

• Agency Mailing Address:

  If you have any problems linking to this funding announcement, please contact the NIH OER Webmaster

• Agency Email Address:

  FBOWebmaster@OD.NIH.GOV

• More Information:

  http://grants.nih.gov/grants/guide/rfa-files/RFA-NS-09-002.html