Genomic Research in AAT-Deficiency and Sarcoidosis study (GRADS) Cooperative Research Project Grant: Genomics and Informatics Center (GIC) (U01)

Post Date

February 2nd 2011

Application Due Date

May 17th 2011

Funding Opportunity Number

RFA-HL-12-014

CFDA Number(s)

93.838

Funding Instrument Type(s)

Cooperative Agreement

Funding Activity Categories

Health

Eligibility Categories

State Governments
County Governments
City or Township Governments
Special District Governments
Independent School Districts
Public and State Controlled Institutions of Higher Education
Federally Recognized Native American Tribal Governments
Public Housing Authorities or Indian Housing Authorities
Non-Federally Recognized Native American Tribal Organizations
Non-Profits With 501 (c) (3) Status With The IRS (Except Higher Education Institutions)
Non-Profits Without 501 (c) (3) Status With The IRS (Except Higher Education Institutions)
Private Institutions of Higher Education
For-Profit Organizations (Except Small Businesses)
Small Businesses
Other

Other Eligible Applicants include the following: Alaska Native and Native Hawaiian Serving Institutions; Eligible Agencies of the Federal Government; Faith-based or Community-based Organizations; Hispanic-serving Institutions; Historically Black Colleges and Universities (HBCUs); Indian/Native American Tribal Governments (Other than Federally Recognized); Non-domestic (non-U.S.) Entities (Foreign Organizations); Regional Organizations; Tribally Controlled Colleges and Universities (TCCUs) ; U.S. Territory or Possession.

Funding

• Estimated Total Funding:

  $12000000

• Award Range:

  $None - $None

Grant Description

The purpose of this funding opportunity announcement (FOA), issued by NHLBI, NIH, is to invite applications to participate in the NHLBI Genomic Research in Alpha-1 Antitrypsin Deficiency and Sarcoidosis (GRADS) program, which will assemble a multidisciplinary team of investigators to conduct state-of-art genomic, microbiomics and phenotypic studies of two serious and understudied conditions that affect the lungs: Alpha-1 Antitrypsin Deficiency (AAT) and sarcoidosis. GRADS will include multiple Clinical Centers and one Genomics and Informatics Center (GIC). This FOA solicits applications for the GIC and runs in parallel with a separate FOA that solicits applications for the Clinical Centers (see RFA-HL-12-013). The four main functions of the GRADS GIC are: (1) coordinate activities for the Clinical Centers that will recruit, clinically and immuno- phenotype AAT and sarcoidosis subjects and obtain biospecimens from them, (2) perform transcriptome and microbiome analyses (mRNA, miRNA, viro-, phylo-chip) of the samples obtained by the Clinical Centers, (3) analyze -omic data, testing for associations with the clinical and immune- phenotypes, and (4) prepare a dataset for deposit in the NHLBI BioLINCC repository (https://biolincc.nhlbi.nih.gov/new_data_set_policy/) for distribution to external investigators. This program will require multidisciplinary research collaboration among genomic and microbiome scientists, bioinformaticians, and clinicians with expertise in these diseases.

Contact Information

• Agency

  Department of Health and Human Services

• Office:

  National Institutes of Health

• Agency Contact:

  NIH OER Webmaster
  FBOWebmaster@OD.NIH.GOV
  

• Agency Mailing Address:

  If you have any problems linking to this funding announcement, please contact the NIH OER Webmaster

• Agency Email Address:

  FBOWebmaster@OD.NIH.GOV

• More Information:

  http://grants.nih.gov/grants/guide/rfa-files/RFA-HL-12-014.html