Next Generation Genetic Association Studies (U01)

Post Date

March 15th 2010

Application Due Date

June 15th 2010

Funding Opportunity Number

RFA-HL-11-006

CFDA Number(s)

93.837
93.838
93.879

Funding Instrument Type(s)

Cooperative Agreement

Funding Activity Categories

Education
Health

Eligibility Categories

State Governments
County Governments
City or Township Governments
Special District Governments
Independent School Districts
Public and State Controlled Institutions of Higher Education
Federally Recognized Native American Tribal Governments
Public Housing Authorities or Indian Housing Authorities
Non-Federally Recognized Native American Tribal Organizations
Non-Profits With 501 (c) (3) Status With The IRS (Except Higher Education Institutions)
Non-Profits Without 501 (c) (3) Status With The IRS (Except Higher Education Institutions)
Private Institutions of Higher Education
For-Profit Organizations (Except Small Businesses)
Small Businesses
Other

Other Eligible Applicants include the following: Alaska Native and Native Hawaiian Serving Institutions; Eligible Agencies of the Federal Government; Faith-based or Community-based Organizations; Hispanic-serving Institutions; Historically Black Colleges and Universities (HBCUs); Indian/Native American Tribal Governments (Other than Federally Recognized); Non-domestic (non-U.S.) Entities (Foreign Organizations); Regional Organizations; Tribally Controlled Colleges and Universities (TCCUs) ; U.S. Territory or Possession.

Funding

• Estimated Total Funding:

  $76000000

• Award Range:

  $None - $None

Grant Description

Purpose. This FOA issued by the National Heart, Lung, and Blood Institute (NHLBI), National Institutes of Health, encourages applications from institutions or organizations that propose to utilize cellular reprogramming, molecular profiling, and genomics to investigate functional aspects of genetic variation in humans. NHLBI is soliciting a phased technology development and implementation program whose goal is to add a functional dimension to genomic studies by combining cellular reprogramming strategies with molecular profiling or cellular assays, followed by integration of this information with existing genotypic and clinical phenotypic data to assess how naturally occurring human genetic variation influences the activities of biological networks in cell-based models of disease. Since the design and conduct of such studies will require several areas of expertise, applicants are encouraged to include multiple PIs on the application. Mechanism of Support. This FOA will utilize the U01 (cooperative agreement) grant mechanism. Applicants will submit a single application organized into three phases, beginning with Phase I which will have technology development to generate induced pluripotent stem (iPS) cells from human samples and differentiate these iPS cells into tissues relevant to heart, lung, blood and sleep (HLBS) diseases. Phase II involves ramping up the technology developed in Phase I for high throughput generation of differentiated cells from iPS cells in population samples. Phase III will utilize technology developed in Phases I and II to test genome wide association study (GWAS) generated functional hypotheses in cell-based models of disease. Applicants may propose Phases I to III or II to III depending on the current state of iPS generation and cell type differentiation technology needed to meet their specific aims. Inclusion of Phase I is dependent on the validation and reproducibility of cell differentiation protocols for the specific cell type(s) proposed in the application.

Contact Information

• Agency

  Department of Health and Human Services

• Office:

  National Institutes of Health

• Agency Contact:

  NIH OER Webmaster
  FBOWebmaster@OD.NIH.GOV
  

• Agency Mailing Address:

  If you have any problems linking to this funding announcement, please contact the NIH OER Webmaster

• Agency Email Address:

  FBOWebmaster@OD.NIH.GOV

• More Information:

  http://grants.nih.gov/grants/guide/rfa-files/RFA-HL-11-006.html