Systems Biology Approach to the Mechanisms of TB Latency and Reactivation (R01)

Post Date

December 9th 2009

Application Due Date

March 24th 2010

Funding Opportunity Number

RFA-HL-10-015

CFDA Number(s)

93.838

Funding Instrument Type(s)

Grant

Funding Activity Categories

Health

Eligibility Categories

State Governments
County Governments
City or Township Governments
Special District Governments
Independent School Districts
Public and State Controlled Institutions of Higher Education
Federally Recognized Native American Tribal Governments
Public Housing Authorities or Indian Housing Authorities
Non-Federally Recognized Native American Tribal Organizations
Non-Profits With 501 (c) (3) Status With The IRS (Except Higher Education Institutions)
Non-Profits Without 501 (c) (3) Status With The IRS (Except Higher Education Institutions)
Private Institutions of Higher Education
For-Profit Organizations (Except Small Businesses)
Small Businesses
Other

Other Eligible Applicants include the following: Alaska Native and Native Hawaiian Serving Institutions; Eligible Agencies of the Federal Government; Faith-based or Community-based Organizations; Hispanic-serving Institutions; Historically Black Colleges and Universities (HBCUs); Indian/Native American Tribal Governments (Other than Federally Recognized); Non-domestic (non-U.S.) Entities (Foreign Organizations); Regional Organizations; Tribally Controlled Colleges and Universities (TCCUs) ; U.S. Territory or Possession.

Funding

• Estimated Total Funding:

  $3450000

• Award Range:

  $None - $250000

Grant Description

Purpose. The National Heart, Lung, and Blood Institute solicits Research Project Grant (R01) applications under this funding opportunity announcement (FOA) to investigate the mechanisms of latency and the reactivation of tuberculosis in the host using integrated systems biology approaches. Systems biology is defined in many ways. For the purposes of this FOA we are using a definition found on the MIT CSBi website: research program that links biologists, computer scientists, and engineers in a multi disciplinary approach to the systematic analysis of complex biological phenomena. The studies should include multiscale computational modeling and focus on host lung responses to Mycobacterium tuberculosis (Mtb) and host-microbial interactions that drive latency and reactivation in humans. To build the theoretical models, human and animal data should be utilized. The studies should integrate the data obtained from omic approaches with biological/immunological data. The models should be such that they can be tested in humans or non-human primates. The use of human samples and or data is required. Applicants are strongly encouraged to use the multiple principal investigator mechanism to facilitate collaborations among investigators with expertise in mathematics and computational multiscale modeling and clinical investigators and experimental biologists who have expertise in tuberculosis, pulmonology, lung biology, immunology, microbiology, genomics, genetics, other omics, and infectious diseases. Applicants are also strongly urged to include bioengineers and physicists in the research groups to enable teams of investigators to take advantage of new and developing technologies likely to be needed both to obtain biological data for building the computational models and for testing hypotheses generated by them. This FOA solicits applications for the TB Systems Biology Centers and runs in parallel with a separate FOA that solicits applications for a Data Coordinating Center (see RFA-HL-10-022).

Contact Information

• Agency

  Department of Health and Human Services

• Office:

  National Institutes of Health

• Agency Contact:

  NIH OER Webmaster
  FBOWebmaster@OD.NIH.GOV
  

• Agency Mailing Address:

  If you have any problems linking to this funding announcement, please contact the NIH OER Webmaster

• Agency Email Address:

  FBOWebmaster@OD.NIH.GOV

• More Information:

  http://grants.nih.gov/grants/guide/rfa-files/RFA-HL-10-015.html