Prematurity and Respiratory Outcomes Program (PROP) (U01)

Post Date

March 10th 2009

Application Due Date

June 2nd 2009

Funding Opportunity Number

RFA-HL-10-007

CFDA Number(s)

93.838

Funding Instrument Type(s)

Cooperative Agreement

Funding Activity Categories

Health

Eligibility Categories

State Governments
County Governments
City or Township Governments
Special District Governments
Independent School Districts
Public and State Controlled Institutions of Higher Education
Federally Recognized Native American Tribal Governments
Public Housing Authorities or Indian Housing Authorities
Non-Federally Recognized Native American Tribal Organizations
Non-Profits With 501 (c) (3) Status With The IRS (Except Higher Education Institutions)
Non-Profits Without 501 (c) (3) Status With The IRS (Except Higher Education Institutions)
Private Institutions of Higher Education
For-Profit Organizations (Except Small Businesses)
Small Businesses
Other

Other Eligible Applicants include the following: Alaska Native and Native Hawaiian Serving Institutions; Eligible Agencies of the Federal Government; Faith-based or Community-based Organizations; Hispanic-serving Institutions; Historically Black Colleges and Universities (HBCUs); Indian/Native American Tribal Governments (Other than Federally Recognized); Non-domestic (non-U.S.) Entities (Foreign Organizations); Regional Organizations; Tribally Controlled Colleges and Universities (TCCUs) ; U.S. Territory or Possession.

Funding

• Estimated Total Funding:

  $18500000

• Award Range:

  $None - $None

Grant Description

Purpose. The National Heart, Lung, and Blood Institute (NHLBI) solicits grant applications from institutions/organizations to participate in a new NHLBI Prematurity and Respiratory Outcomes Program (PROP). This cooperative, multidisciplinary scientific group will investigate hypotheses on the molecular mechanisms that contribute to respiratory disease risk of the premature newborn with the long-term goal of improving outcomes in the first year of life. The Program will consist of up to five Clinical Research Centers (CRC), a Steering Committee, and a Data Coordinating Center (DCC). CRC applicants will each propose a detailed hypothesis of a mechanism that contributes to respiratory disease risk of a defined cohort, as well as innovative molecular/functional biomarkers to define the cohort, predict the severity of respiratory outcomes for that cohort, and serve as surrogate endpoints in evaluation of risk modification. This program will require collaborations between neonatologists, pulmonologists, and scientists with expertise in cutting-edge technology (such as bioengineering, molecular genetics, or imaging). Use of the multiple PI mechanism is strongly encouraged. Mechanism of Support. This FOA will utilize the Research Project Cooperative Agreement (U01) mechanism of support. Funds Available and Anticipated Number of Awards. The NHLBI intends to commit approximately $1,500,000 total costs for FY2010. The total amount to be awarded for the Prematurity and Respiratory Outcomes Program will be a maximum of $18,500,000 total costs for the 5-year project period. It is anticipated that up to 5 CRCs and 1 DCC will be awarded.

Contact Information

• Agency

  Department of Health and Human Services

• Office:

  National Institutes of Health

• Agency Contact:

  NIH OER Webmaster
  FBOWebmaster@OD.NIH.GOV
  

• Agency Mailing Address:

  If you have any problems linking to this funding announcement, please contact the NIH OER Webmaster

• Agency Email Address:

  FBOWebmaster@OD.NIH.GOV

• More Information:

  http://grants.nih.gov/grants/guide/rfa-files/RFA-HL-10-007.html