Identification of Biomarkers for Early Detection of Environmentally-Induced Mitochondrial Dysfunction (R01)

Post Date

November 30th 2010

Application Due Date

February 3rd 2011

Funding Opportunity Number

RFA-ES-11-007

CFDA Number(s)

93.113

Funding Instrument Type(s)

Grant

Funding Activity Categories

Environment
Health

Eligibility Categories

State Governments
County Governments
City or Township Governments
Special District Governments
Independent School Districts
Public and State Controlled Institutions of Higher Education
Federally Recognized Native American Tribal Governments
Public Housing Authorities or Indian Housing Authorities
Non-Federally Recognized Native American Tribal Organizations
Non-Profits With 501 (c) (3) Status With The IRS (Except Higher Education Institutions)
Non-Profits Without 501 (c) (3) Status With The IRS (Except Higher Education Institutions)
Private Institutions of Higher Education
For-Profit Organizations (Except Small Businesses)
Small Businesses
Other

Other Eligible Applicants include the following: Alaska Native and Native Hawaiian Serving Institutions; Eligible Agencies of the Federal Government; Faith-based or Community-based Organizations; Hispanic-serving Institutions; Historically Black Colleges and Universities (HBCUs); Indian/Native American Tribal Governments (Other than Federally Recognized); Non-domestic (non-U.S.) Entities (Foreign Organizations); Regional Organizations; Tribally Controlled Colleges and Universities (TCCUs) ; U.S. Territory or Possession.

Funding

• Estimated Total Funding:

  $2500000

• Award Range:

  $None - $None

Grant Description

This funding opportunity announcement (FOA) encourages grant applications from institutions/organizations to develop biomarkers of mitochondrial dysfunction using animal models and other experimental models that can help to identify environmental stressors that inhibit normal mitochondrial function, improve our mechanistic understanding of the effects of mitochondrial toxicants, and develop approaches and candidate markers that will serve as the basis for developing biomarkers of early mitochondrial dysfunction in human population studies linking exposure to disease. Mitochondrial biology is complex, with different responses to stressors, diet composition, and genetic factors observed in different tissues and at different stages of development. Before early biomarkers of mitochondrial dysfunction can be fully developed for human studies, a number of important issues need to be addressed, including enhancing the understanding of how the more severe effects on mitochondrial function in target tissues relate to milder effects in surrogate tissues, understanding whether alterations in mitochondrial endpoints are adaptive or adverse (transient or persistent) effects, and determining which endpoints signal early effects on mitochondrial function before more severe tissue phenotypes are apparent. Many of these questions can be addressed through development of relevant animal and other experimental models to identify robust markers of mitochondrial dysfunction associated with genetic and environmental factors.

Contact Information

• Agency

  Department of Health and Human Services

• Office:

  National Institutes of Health

• Agency Contact:

  NIH OER Webmaster
  FBOWebmaster@OD.NIH.GOV
  

• Agency Mailing Address:

  If you have any problems linking to this funding announcement, please contact the NIH OER Webmaster

• Agency Email Address:

  FBOWebmaster@OD.NIH.GOV

• More Information:

  http://grants.nih.gov/grants/guide/rfa-files/RFA-ES-11-007.html