Validation and Field Testing of Novel Biomarkers of Response to Environmental Stressors (R01)

Post Date

August 13th 2010

Application Due Date

October 21st 2010

Funding Opportunity Number

RFA-ES-10-008

CFDA Number(s)

93.113
93.273
93.279

Funding Instrument Type(s)

Grant

Funding Activity Categories

Education
Environment
Health

Eligibility Categories

State Governments
County Governments
City or Township Governments
Special District Governments
Independent School Districts
Public and State Controlled Institutions of Higher Education
Federally Recognized Native American Tribal Governments
Public Housing Authorities or Indian Housing Authorities
Non-Federally Recognized Native American Tribal Organizations
Non-Profits With 501 (c) (3) Status With The IRS (Except Higher Education Institutions)
Non-Profits Without 501 (c) (3) Status With The IRS (Except Higher Education Institutions)
Private Institutions of Higher Education
For-Profit Organizations (Except Small Businesses)
Small Businesses
Other

Other Eligible Applicants include the following: Alaska Native and Native Hawaiian Serving Institutions; Eligible Agencies of the Federal Government; Faith-based or Community-based Organizations; Hispanic-serving Institutions; Historically Black Colleges and Universities (HBCUs); Indian/Native American Tribal Governments (Other than Federally Recognized); Non-domestic (non-U.S.) Entities (Foreign Organizations); Regional Organizations; Tribally Controlled Colleges and Universities (TCCUs) ; U.S. Territory or Possession.

Funding

• Estimated Total Funding:

  $2555000

• Award Range:

  $None - $300000

Grant Description

Purpose. This FOA solicits grant applications from institutions/organizations to conduct pilot testing of novel candidate biomarkers and technologies that measure biological responses to chemical toxicants and other environmental stressors. Through collaborations with existing human population studies, investigators will conduct a rigorous evaluation of the performance of novel biomarkers and technologies under a range of exposure levels and collection and storage conditions, to establish the potential and feasibility of applying these novel approaches to large-scale epidemiology and gene-environment studies. Applicants will be expected to describe characteristics of their candidate biomarkers or technologies (e.g., laboratory validation studies, limits of detection, and preliminary data from discovery cohort studies) that demonstrate their suitability for further pilot testing. The goal of this 2-year program is to assess the performance (including testing for sensitivity, specificity, reliability and reproducibility) of these novel approaches in independent cohorts. The emphasis of this FOA is the validation of promising biomarkers and technologies; projects to discover and develop new technology and biomarkers of response are not appropriate to this solicitation and will be returned as nonresponsive. Mechanism of Support. This FOA will utilize the R01 award mechanism and runs in parallel with an FOA of similar scientific scope, RFA-ES-10-007, that encourages applications to pilot test and validate new tools for measuring exposure to chemical and lifestyle stressors. Funds Available and Anticipated Number of Awards. NIEHS, NIAAA, and NIDA intend to commit a combined total of $2,555,000 to fund 5 to 6 awards through this FOA.

Contact Information

• Agency

  Department of Health and Human Services

• Office:

  National Institutes of Health

• Agency Contact:

  NIH OER Webmaster
  FBOWebmaster@OD.NIH.GOV
  

• Agency Mailing Address:

  If you have any problems linking to this funding announcement, please contact the NIH OER Webmaster

• Agency Email Address:

  FBOWebmaster@OD.NIH.GOV

• More Information:

  http://grants.nih.gov/grants/guide/rfa-files/RFA-ES-10-008.html