Optimizing Recovery and Preservation of Endogenous Insulin Secretion in Individuals with Prediabetes or Recent Onset of Type 2 Diabetes (U01)

Post Date

November 24th 2010

Application Due Date

March 24th 2011

Funding Opportunity Number

RFA-DK-10-013

CFDA Number(s)

93.847

Funding Instrument Type(s)

Cooperative Agreement

Funding Activity Categories

Food and Nutrition
Health

Eligibility Categories

State Governments
County Governments
City or Township Governments
Special District Governments
Independent School Districts
Public and State Controlled Institutions of Higher Education
Federally Recognized Native American Tribal Governments
Public Housing Authorities or Indian Housing Authorities
Non-Federally Recognized Native American Tribal Organizations
Non-Profits With 501 (c) (3) Status With The IRS (Except Higher Education Institutions)
Non-Profits Without 501 (c) (3) Status With The IRS (Except Higher Education Institutions)
Private Institutions of Higher Education
For-Profit Organizations (Except Small Businesses)
Small Businesses
Other

Other Eligible Applicants include the following: Alaska Native and Native Hawaiian Serving Institutions; Eligible Agencies of the Federal Government; Faith-based or Community-based Organizations; Hispanic-serving Institutions; Historically Black Colleges and Universities (HBCUs); Indian/Native American Tribal Governments (Other than Federally Recognized); Regional Organizations; Tribally Controlled Colleges and Universities (TCCUs) ; U.S. Territory or Possession.

Funding

• Estimated Total Funding:

  $4000000

• Award Range:

  $None - $None

Grant Description

This FOA, issued by the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK), solicits applications for clinical studies to investigate strategies that promote the recovery and maintenance of endogenous insulin secretion among individuals who have prediabetes or are early in the course of type 2 diabetes. Specifically, the aim of this initiative is 1) To assess whether short, intensive interventions can substantially improve the pattern and magnitude of the endogenous insulin response, the extent to which recovery is possible and to identify the factors associated with recovery and retention of endogenous insulin secretion, and 2) To determine the duration of the effect and whether this will facilitate achieving better glucose control. In addition, studies may seek to identify biomarkers that will simplify assessment of beta cell function and improve prediction of whether a given individual will respond positively to the intervention. Although each investigator will propose and conduct a unique protocol, collaboration will be required among awardees to establish common definitions, measures and procedures to promote comparisons of data across protocols.

Contact Information

• Agency

  Department of Health and Human Services

• Office:

  National Institutes of Health

• Agency Contact:

  NIH OER Webmaster
  FBOWebmaster@OD.NIH.GOV
  

• Agency Mailing Address:

  If you have any problems linking to this funding announcement, please contact the NIH OER Webmaster

• Agency Email Address:

  FBOWebmaster@OD.NIH.GOV

• More Information:

  http://grants.nih.gov/grants/guide/rfa-files/RFA-DK-10-013.html