Fine Mapping and Function of Genes for Type 1 Diabetes (DP3)

Post Date

October 16th 2008

Application Due Date

March 30th 2009

Funding Opportunity Number

RFA-DK-08-006

CFDA Number(s)

93.847

Funding Instrument Type(s)

Grant

Funding Activity Categories

Health

Eligibility Categories

Public and State Controlled Institutions of Higher Education
Non-Profits With 501 (c) (3) Status With The IRS (Except Higher Education Institutions)
Non-Profits Without 501 (c) (3) Status With The IRS (Except Higher Education Institutions)
Private Institutions of Higher Education
For-Profit Organizations (Except Small Businesses)
Small Businesses
Other

Other Eligible Applicants include the following: Alaska Native and Native Hawaiian Serving Institutions; Eligible Agencies of the Federal Government; Hispanic-serving Institutions; Historically Black Colleges and Universities (HBCUs); Non-domestic (non-U.S.) Entities (Foreign Organizations); Tribally Controlled Colleges and Universities (TCCUs) .

Funding

• Estimated Total Funding:

  $20000000

• Award Range:

  $None - $None

Grant Description

-Purpose. This FOA issued by the National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, solicits Research Project Grant (DP3) applications from institutions/organizations for research on projects to carry out fine mapping studies as well as to investigate the function of the genes involved in type 1 diabetes. To date, genome-wide association studies (GWAS) of type 1 diabetes have yielded promising results.ÊHowever, follow-up studies are needed to eliminate false positives, extend the findings to diverse populations (diverse in terms of ethnicity or environmental exposures) and narrow the association interval.ÊThe purpose of this funding opportunity is to provide support for replication and fine-mapping studies of genetic regions putatively associated with type 1 diabetes.ÊIn addition, studies of the function of the genes identified and the mechanisms by which they may alter risk are needed. This initiative will also solicit proposals on the application of new technologies to genetics of type 1 diabetes and the study of the role of these genes in the etiopathogenesis of type 1 DM. The identification of these genes and function will help define etiological pathways and leads for new therapeutic targets. -Mechanism of Support. This FOA will utilize the DP3 grant mechanism. -Funds Available and Anticipated Number of Awards. The total funding for this five year program this year is $20 million for the five year period. It is anticipated that 4-10 awards will be made.Ê

Contact Information

• Agency

  Department of Health and Human Services

• Office:

  National Institutes of Health

• Agency Contact:

  NIH OER Webmaster
  FBOWebmaster@OD.NIH.GOV
  

• Agency Mailing Address:

  If you have any problems linking to this funding announcement, please contact the NIH OER Webmaster

• Agency Email Address:

  FBOWebmaster@OD.NIH.GOV

• More Information:

  http://grants.nih.gov/grants/guide/rfa-files/RFA-DK-08-006.html