Brain Imaging Studies of Negative Reinforcement in Humans (R21)

Post Date

November 5th 2008

Application Due Date

February 19th 2009

Funding Opportunity Number

RFA-DA-09-009

CFDA Number(s)

93.279

Funding Instrument Type(s)

Grant

Funding Activity Categories

Education
Health

Eligibility Categories

State Governments
County Governments
City or Township Governments
Special District Governments
Independent School Districts
Public and State Controlled Institutions of Higher Education
Federally Recognized Native American Tribal Governments
Public Housing Authorities or Indian Housing Authorities
Non-Federally Recognized Native American Tribal Organizations
Non-Profits With 501 (c) (3) Status With The IRS (Except Higher Education Institutions)
Non-Profits Without 501 (c) (3) Status With The IRS (Except Higher Education Institutions)
Private Institutions of Higher Education
For-Profit Organizations (Except Small Businesses)
Small Businesses
Other

Other Eligible Applicants include the following: Alaska Native and Native Hawaiian Serving Institutions; Eligible Agencies of the Federal Government; Faith-based or Community-based Organizations; Hispanic-serving Institutions; Historically Black Colleges and Universities (HBCUs); Indian/Native American Tribal Governments (Other than Federally Recognized); Non-domestic (non-U.S.) Entities (Foreign Organizations); Regional Organizations; Tribally Controlled Colleges and Universities (TCCUs) ; U.S. Territory or Possession.

Funding

• Estimated Total Funding:

  $3000000

• Award Range:

  $None - $200000

Grant Description

Purpose. This FOA issued by National Institute on Drug Abuse, National Institutes of Health, solicits Exploratory/Developmental Grant (R21) applications from institutions/ organizations that propose to investigate brain processes in humans underlying how aversive events control behavior in order to stimulate a program of clinical neuroscience research on negative reinforcement / avoidance learning.On the basis of pre-clinical studies, negative reinforcement has re-emerged as a contributing factor in the basic processes of substance abuse.The range of processes engaged by the human brain to avoid aversive outcomes are much less well understood than that of brain processes engaged by positive outcomes. For the purpose of this FOA negative reinforcement and avoidance learning are considered synonymous and refer to behaviors and cognitive strategies that are learned and maintained in order to minimize or eliminate the occurrence of aversive events. Aversive events may be either environmental stimuli or internal states. Applications for this FOA are expected to propose exploratory, hypotheses-generating or proof of concept studies regarding the brain regions or processes in humans that underlie avoidance learning including behaviors and cognitive strategies maintained by negative reinforcement. This FOA is also appropriate for the development of new tasks in humans that may be used in future brain imaging studies to target specific brain processing areas affected by negative reinforcement/avoidance learning. The studies proposed in response to this FOA may be conducted in healthy individuals, substance-abusing populations (current or abstinent) or individuals at risk for substance abuse.However, all applications must address how the proposed investigations are relevant to advancing the understanding of substance abuse.

Contact Information

• Agency

  Department of Health and Human Services

• Office:

  National Institutes of Health

• Agency Contact:

  NIH OER Webmaster
  FBOWebmaster@OD.NIH.GOV
  

• Agency Mailing Address:

  If you have any problems linking to this funding announcement, please contact the NIH OER Webmaster

• Agency Email Address:

  FBOWebmaster@OD.NIH.GOV

• More Information:

  http://grants.nih.gov/grants/guide/rfa-files/RFA-DA-09-009.html