Genome Characterization Centers and Genome Data Analysis Centers for The Cancer Genome Atlas Research Network (TCGA)[U24]

Post Date

January 7th 2009

Application Due Date

March 13th 2009

Funding Opportunity Number

RFA-CA-09-010

CFDA Number(s)

93.393
93.394
93.395
93.396
93.397
93.398
93.399

Funding Instrument Type(s)

Cooperative Agreement

Funding Activity Categories

Education
Health

Eligibility Categories

Public and State Controlled Institutions of Higher Education
Non-Profits With 501 (c) (3) Status With The IRS (Except Higher Education Institutions)
Non-Profits Without 501 (c) (3) Status With The IRS (Except Higher Education Institutions)
Private Institutions of Higher Education
For-Profit Organizations (Except Small Businesses)
Small Businesses
Other

Other Eligible Applicants include the following: Eligible Agencies of the Federal Government; Non-domestic (non-U.S.) Entities (Foreign Organizations).

Funding

• Estimated Total Funding:

  $18000000

• Award Range:

  $None - $None

Grant Description

Purpose. This funding opportunity announcement (FOA) is designed to support The Cancer Genome Atlas (TCGA) research network. The overall goal of this phase of the TCGA initiative is to provide genome-wide catalogs of genomic alterations in 20-25 different types of human cancer that could be used to identify and accelerate the development of new diagnostic and prognostic markers, new targets for pharmaceutical interventions, and new cancer prevention and treatment strategies.Under this FOA, the NCI solicits applications for two types of centers. (1) Genome Characterization Centers (GCCs); and (2) Genome Data Analysis Centers (GDACs, that must be oriented on one of two permissible types of analytical pipelines). An applicant/institution may submit one application for either type of centers or two applications for two different types (with certain restrictions regarding subtypes of GDACs). GCCs will utilize novel high-throughput, high resolution technologies to comprehensively (i.e., genome-wide) detect genomic, epigenomic and transcriptome aberrations including: alterations in chromosome segment copy numbers, translocations, loss of heterozygosity, altered DNA methylation patterns and changes in gene expression, which may play a role in cancer. GDACs will focus on the integration and analysis of data generated by the GCCs and other TCGA components, development of innovative bioinformatic and computational tools and the performance of advanced bioinformatic analyses including, but not limited to: systems biology approaches to discovery, pathway analysis models, and integrative data analysis methods with accompanying visualization tools to identify complex genomic changes; and integrated cancer biology and translational discovery models that will increase our understanding of cancer as a disease process.Prior contribution to the TCGA Pilot Project is not required and all qualified institutions and individuals are encouraged to apply to this FOA.

Contact Information

• Agency

  Department of Health and Human Services

• Office:

  National Institutes of Health

• Agency Contact:

  NIH OER Webmaster
  FBOWebmaster@OD.NIH.GOV
  

• Agency Mailing Address:

  If you have any problems linking to this funding announcement, please contact the NIH OER Webmaster

• Agency Email Address:

  FBOWebmaster@OD.NIH.GOV

• More Information:

  http://grants.nih.gov/grants/guide/rfa-files/RFA-CA-09-010.html