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Next Generation PrEP II (R01)

Post Date

March 30th 2011

Application Due Date

September 8th 2011

Funding Opportunity Number

RFA-AI-11-023

CFDA Number(s)

93.855
93.856

Funding Instrument Type(s)

Grant

Funding Activity Categories

Health

Eligibility Categories

State Governments
County Governments
City or Township Governments
Special District Governments
Independent School Districts
Public and State Controlled Institutions of Higher Education
Federally Recognized Native American Tribal Governments
Public Housing Authorities or Indian Housing Authorities
Non-Federally Recognized Native American Tribal Organizations
Non-Profits With 501 (c) (3) Status With The IRS (Except Higher Education Institutions)
Non-Profits Without 501 (c) (3) Status With The IRS (Except Higher Education Institutions)
Private Institutions of Higher Education
For-Profit Organizations (Except Small Businesses)
Small Businesses
Other

Other Eligible Applicants include the following: Alaska Native and Native Hawaiian Serving Institutions; Eligible Agencies of the Federal Government; Faith-based or Community-based Organizations; Hispanic-serving Institutions; Historically Black Colleges and Universities (HBCUs); Indian/Native American Tribal Governments (Other than Federally Recognized); Non-domestic (non-U.S.) Entities (Foreign Organizations); Regional Organizations; Tribally Controlled Colleges and Universities (TCCUs) ; U.S. Territory or Possession; Foreign (non-U.S.) components of U.S. Organizations are allowed.

Funding

  • Estimated Total Funding:

    $3200000

  • Award Range:

    $None - $300000

Grant Description

Develop the basic and preclinical framework needed for development of second and subsequent generations of PrEP agents Create a rational pipeline for the discovery of New Molecular Entities (NMEs) and the identification of existing antiretrovirals (including those that are approved for HIV treatment, and those that are not approved but may have clinical data) that can be used for the next generation of PrEP agents Develop preclinical algorithms with clear go/no go criteria for identifying and prioritizing PrEP candidates for advancement to clinical evaluation Generate PK/PD models to assess protective effects at mucosal sites of HIV transmission Conduct proof-of-concept safety and efficacy studies in animal models

Contact Information


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