Allergen Epitope Research and Validation Cnters (U19)

Post Date

April 7th 2011

Application Due Date

July 22nd 2011

Funding Opportunity Number

RFA-AI-11-013

CFDA Number(s)

93.855
93.856

Funding Instrument Type(s)

Cooperative Agreement

Funding Activity Categories

Health

Eligibility Categories

State Governments
County Governments
City or Township Governments
Special District Governments
Independent School Districts
Public and State Controlled Institutions of Higher Education
Federally Recognized Native American Tribal Governments
Public Housing Authorities or Indian Housing Authorities
Non-Federally Recognized Native American Tribal Organizations
Non-Profits With 501 (c) (3) Status With The IRS (Except Higher Education Institutions)
Non-Profits Without 501 (c) (3) Status With The IRS (Except Higher Education Institutions)
Private Institutions of Higher Education
For-Profit Organizations (Except Small Businesses)
Small Businesses
Other

Other Eligible Applicants include the following: Alaska Native and Native Hawaiian Serving Institutions; Eligible Agencies of the Federal Government; Faith-based or Community-based Organizations; Hispanic-serving Institutions; Historically Black Colleges and Universities (HBCUs); Indian/Native American Tribal Governments (Other than Federally Recognized); Non-domestic (non-U.S.) Entities (Foreign Organizations); Regional Organizations; Tribally Controlled Colleges and Universities (TCCUs) ; U.S. Territory or Possession; Foreign (non-U.S.) components of U.S. Organizations are allowed.

Funding

• Estimated Total Funding:

  $2800000

• Award Range:

  $None - $None

Grant Description

The purpose of this FOA is to capitalize on the availability of well characterized T cell allergen epitopes to study allergen-specific immune responses.. As part of the characterization and validation of these allergen T cell epitopes, there is a need to conduct mechanistic studies that focus on the progression and/or changes in the severity of seasonal or perennial allergic diseases (e.g. seasonal allergic rhinitis, asthma exacerbations triggered by pet dander), as well as the changes resulting from therapeutic intervention in allergic disease, such as immunotherapy for seasonal, perennial, or food allergies. Programs should focus on mechanistic assessment of T cell allergen epitopes to illuminate the T cell phenotypes, their function and contribution to allergen-specific T-cell memory. Limited novel T cell allergen epitope identification will also be supported under this FOA, but only as a companion to, and extension of, mechanistic studies of T cell responses to existing allergen epitopes.

Contact Information

• Agency

  Department of Health and Human Services

• Office:

  National Institutes of Health

• Agency Contact:

  NIH OER Webmaster
  FBOWebmaster@OD.NIH.GOV
  

• Agency Mailing Address:

  If you have any problems linking to this funding announcement, please contact the NIH OER Webmaster

• Agency Email Address:

  FBOWebmaster@OD.NIH.GOV

• More Information:

  http://grants.nih.gov/grants/guide/rfa-files/RFA-AI-11-013.html