Next Generation PrEP (R01)

Post Date

May 27th 2010

Application Due Date

November 2nd 2010

Funding Opportunity Number

RFA-AI-10-012

CFDA Number(s)

93.855
93.856

Funding Instrument Type(s)

Grant

Funding Activity Categories

Health

Eligibility Categories

State Governments
County Governments
City or Township Governments
Special District Governments
Independent School Districts
Public and State Controlled Institutions of Higher Education
Federally Recognized Native American Tribal Governments
Public Housing Authorities or Indian Housing Authorities
Non-Federally Recognized Native American Tribal Organizations
Non-Profits With 501 (c) (3) Status With The IRS (Except Higher Education Institutions)
Non-Profits Without 501 (c) (3) Status With The IRS (Except Higher Education Institutions)
Private Institutions of Higher Education
For-Profit Organizations (Except Small Businesses)
Small Businesses
Other

Other Eligible Applicants include the following: Alaska Native and Native Hawaiian Serving Institutions; Eligible Agencies of the Federal Government; Faith-based or Community-based Organizations; Hispanic-serving Institutions; Historically Black Colleges and Universities (HBCUs); Indian/Native American Tribal Governments (Other than Federally Recognized); Non-domestic (non-U.S.) Entities (Foreign Organizations); Regional Organizations; Tribally Controlled Colleges and Universities (TCCUs) ; U.S. Territory or Possession.

Funding

• Estimated Total Funding:

  $1800000

• Award Range:

  $None - $None

Grant Description

Purpose. The National Institute of Allergy and Infectious Diseases (NIAID) encourages applications from institutions/organizations to participate in this Funding Opportunity Announcement (FOA), Next Generation PrEP. The purpose of this FOA is to: Develop the basic and preclinical framework needed for development of second and subsequent generations of PrEP agents; Create a rational pipeline for the discovery of New Molecular Entities (NMEs) and the identification of existing antiretrovirals (approved for HIV treatment, and those that are not approved but may have extensive clinical data) that can be used for the next generation of PrEP agents; Develop preclinical algorithms with clear go/no go criteria for identifying and prioritizing PrEP candidates for advancement to clinical evaluation; Generate PK/PD models to assess protective effects at mucosal sites of HIV transmission; and Conduct proof-of-concept safety and efficacy studies in animal models. Mechanism of Support. This FOA will utilize the NIH Research project (R01) grant mechanism. Funds Available and Anticipated Number of Awards. NIAID intends to commit approximately $1.8M in FY 2011 to fund 3-5 applications submitted in response to this FOA. Awards issued under this FOA are contingent upon the availability of funds and the submission of a sufficient number of meritorious applications

Contact Information

• Agency

  Department of Health and Human Services

• Office:

  National Institutes of Health

• Agency Contact:

  NIH OER Webmaster
  FBOWebmaster@OD.NIH.GOV
  

• Agency Mailing Address:

  If you have any problems linking to this funding announcement, please contact the NIH OER Webmaster

• Agency Email Address:

  FBOWebmaster@OD.NIH.GOV

• More Information:

  http://grants.nih.gov/grants/guide/rfa-files/RFA-AI-10-012.html