Impact of Aging on Currently Employed Animal Models of Disease and Chronic Conditions: Demonstration Projects (UH2/UH3)

Post Date

November 2nd 2015

Application Due Date

January 6th 2016

Funding Opportunity Number

RFA-AG-16-020

CFDA Number(s)

93.113
93.121
93.853
93.855
93.856
93.866

Funding Instrument Type(s)

Cooperative Agreement

Funding Activity Categories

Environment
Health

Eligibility Categories

State Governments
County Governments
City or Township Governments
Special District Governments
Independent School Districts
Public and State Controlled Institutions of Higher Education
Federally Recognized Native American Tribal Governments
Public Housing Authorities or Indian Housing Authorities
Non-Federally Recognized Native American Tribal Organizations
Non-Profits With 501 (c) (3) Status With The IRS (Except Higher Education Institutions)
Non-Profits Without 501 (c) (3) Status With The IRS (Except Higher Education Institutions)
Private Institutions of Higher Education
For-Profit Organizations (Except Small Businesses)
Small Businesses
Other

Other Eligible Applicants include the following: Alaska Native and Native Hawaiian Serving Institutions; Asian American Native American Pacific Islander Serving Institutions (AANAPISISs); Eligible Agencies of the Federal Government; Faith-based or Community-based Organizations; Hispanic-serving Institutions; Historically Black Colleges and Universities (HBCUs); Indian/Native American Tribal Governments (Other than Federally Recognized); Non-domestic (non-U.S.) Entities (Foreign Organizations); Regional Organizations; Tribally Controlled Colleges and Universities (TCCUs) ; U.S. Territory or Possession; Non-domestic (non-U.S.) Entities (Foreign Institutions) are not eligible to apply. Non-domestic (non-U.S.) components of U.S. Organizations are not eligible to apply. Foreign components, as defined in the NIH Grants Policy Statement, are not allowed.

Funding

• Estimated Total Funding:

  $2100000

• Award Range:

  $None - $None

Grant Description

The goal of this FOA is to test whether or not the ages of laboratory animals is an important consideration in experimental outcomes in the study of disease pathology, degenerative condition, response to therapy, intervention or environmental exposure. The majority of studies of human conditions and diseases in laboratory animals are done using young animals. Young animals may be appropriate for study of human diseases that are prevalent in young humans. However, older animals may be more appropriate for study of human diseases that are prevalent in older humans. While this is a testable hypothesis, there have been obstacles to performing such studies: they are more costly and take more time than studies with young animals. Nevertheless, studies in older animals may be critical to advancing basic research and translational studies from animal models to human populations where aging is itself known to impact the condition, disease or response. To test this assumption, this FOA will provide funds for demonstration projects to address two questions: 1. Does the age of the model organism influence experimental outcomes? 2. Are older animals better models of experimental studies for conditions, interventions, diseases or exposures for which aging is a risk factor of the human condition (for which the model was developed)?

Contact Information

• Agency

  Department of Health and Human Services

• Office:

  National Institutes of Health

• Agency Contact:

  NIH OER Webmaster
  FBOWebmaster@OD.NIH.GOV
  

• Agency Mailing Address:

  If you have any problems linking to this funding announcement, please contact the NIH OER Webmaster

• Agency Email Address:

  FBOWebmaster@OD.NIH.GOV

• More Information:

  http://grants.nih.gov/grants/guide/rfa-files/RFA-AG-16-020.html