Short-term Measurements of Improved Physical and Molecular Resilience in Pre-clinical Models (R01)

Post Date

August 11th 2015

Application Due Date

November 4th 2015

Funding Opportunity Number

RFA-AG-16-006

CFDA Number(s)

93.866

Funding Instrument Type(s)

Grant

Funding Activity Categories

Health

Eligibility Categories

State Governments
County Governments
City or Township Governments
Special District Governments
Independent School Districts
Public and State Controlled Institutions of Higher Education
Federally Recognized Native American Tribal Governments
Public Housing Authorities or Indian Housing Authorities
Non-Federally Recognized Native American Tribal Organizations
Non-Profits With 501 (c) (3) Status With The IRS (Except Higher Education Institutions)
Non-Profits Without 501 (c) (3) Status With The IRS (Except Higher Education Institutions)
Private Institutions of Higher Education
For-Profit Organizations (Except Small Businesses)
Small Businesses
Other

Other Eligible Applicants include the following: Alaska Native and Native Hawaiian Serving Institutions; Asian American Native American Pacific Islander Serving Institutions (AANAPISISs); Eligible Agencies of the Federal Government; Faith-based or Community-based Organizations; Hispanic-serving Institutions; Historically Black Colleges and Universities (HBCUs); Indian/Native American Tribal Governments (Other than Federally Recognized); Non-domestic (non-U.S.) Entities (Foreign Organizations); Regional Organizations; Tribally Controlled Colleges and Universities (TCCUs) ; U.S. Territory or Possession.

Funding

• Estimated Total Funding:

  $2000000

• Award Range:

  $None - $250000

Grant Description

This Funding Opportunity Announcement (FOA) invites applications to develop short-term surrogate tests that provide a comprehensive measure of resilience in animal models of aging. Applicants may also include aims to assess resilience in humans to identical or analogous stressors to those proposed for their animal model studies. Resilience is defined here as the ability of an organism to adequately respond to physical or molecular challenges or stresses. Greater resilience has been hypothesized to correlate with longevity and better healthspan, but appropriate methodology to test this in animal models is currently lacking. The purpose of this FOA is to develop tests that can be used to measure resilience to physical or molecular stresses, but does not include psychological or social stressors. The outcomes should lead to short-term tests of resilience that are predictive of subsequent health. In the context of animal studies, this predictability should be tested against manipulations known to increase lifespan and healthspan.

Contact Information

• Agency

  Department of Health and Human Services

• Office:

  National Institutes of Health

• Agency Contact:

  NIH OER Webmaster
  FBOWebmaster@OD.NIH.GOV
  

• Agency Mailing Address:

  If you have any problems linking to this funding announcement, please contact the NIH OER Webmaster

• Agency Email Address:

  FBOWebmaster@OD.NIH.GOV

• More Information:

  http://grants.nih.gov/grants/guide/rfa-files/RFA-AG-16-006.html