Mechanisms Mediating Changes in Central Regulation of Bone Mass (R01)

Post Date

August 3rd 2010

Application Due Date

October 14th 2010

Funding Opportunity Number

RFA-AG-11-006

CFDA Number(s)

93.866

Funding Instrument Type(s)

Grant

Funding Activity Categories

Health

Eligibility Categories

State Governments
County Governments
City or Township Governments
Special District Governments
Independent School Districts
Public and State Controlled Institutions of Higher Education
Federally Recognized Native American Tribal Governments
Public Housing Authorities or Indian Housing Authorities
Non-Federally Recognized Native American Tribal Organizations
Non-Profits With 501 (c) (3) Status With The IRS (Except Higher Education Institutions)
Non-Profits Without 501 (c) (3) Status With The IRS (Except Higher Education Institutions)
Private Institutions of Higher Education
For-Profit Organizations (Except Small Businesses)
Small Businesses
Other

Other Eligible Applicants include the following: Alaska Native and Native Hawaiian Serving Institutions; Eligible Agencies of the Federal Government; Faith-based or Community-based Organizations; Hispanic-serving Institutions; Historically Black Colleges and Universities (HBCUs); Indian/Native American Tribal Governments (Other than Federally Recognized); Non-domestic (non-U.S.) Entities (Foreign Organizations); Regional Organizations; Tribally Controlled Colleges and Universities (TCCUs) ; U.S. Territory or Possession.

Funding

• Estimated Total Funding:

  $1500000

• Award Range:

  $None - $250000

Grant Description

Purpose This FOA issued by the National Institute on Aging (NIA), National Institutes of Health (NIH), solicits Research Project Grant (R01) applications from institutions/ organizations that propose to investigate neural, neuroendocrine and/or related integrative physiological mechanisms that mediate age dependent changes in bone metabolism and health. The discovery that leptin, secreted by adipocytes, regulates bone mass through a central relay involving serotonergic neurons has generated considerable interest and raised many additional questions about the identity of neural mediator(s) linking the brain to skeletal physiology as well as the potential involvement of other factors whether they be neural/hypothalamic factors (Serotonin, TSH and FSH, ephrins, dynorphins, endocannabiniods/receptors) or other factors such as ACTH, as well as distant tissues/organs such as adipose tissue) in regulating bone mass as well as distant tissues/organs. In addition, recent reports indicate that direct innervations are important in mechanical load sensing and bone remodeling. Furthermore, in view of the well documented age-related changes in neuroendocrine activity, this emerging field of research will significantly reshape our understanding of mechanisms modulating age-related changes in bone mass (increase or decrease in bone mass and/or the etiology of osteoporosis). We are interested in studies to identify and characterize age-related changes in these factors that serve to integrate activity influencing bone mass as well as integrative cross talk mechanisms (neural, endocrine, immune or novel) that coordinate these signaling pathways. Mechanism of Support. This FOA will utilize the R01 grant mechanism. Funds Available and Anticipated Number of Awards NIA will fund 3-5 applications with annual budgets up to and including $250,000 in direct costs for up to 5 years depending upon receipt of an adequate number of meritorious applications.

Contact Information

• Agency

  Department of Health and Human Services

• Office:

  National Institutes of Health

• Agency Contact:

  NIH OER Webmaster
  FBOWebmaster@OD.NIH.GOV
  

• Agency Mailing Address:

  If you have any problems linking to this funding announcement, please contact the NIH OER Webmaster

• Agency Email Address:

  FBOWebmaster@OD.NIH.GOV

• More Information:

  http://grants.nih.gov/grants/guide/rfa-files/RFA-AG-11-006.html