Mechanism of Alcohol-Induced Organ Damage (R01)

Post Date

January 21st 2009

Application Due Date

April 2nd 2009

Funding Opportunity Number

RFA-AA-09-006

CFDA Number(s)

93.273

Funding Instrument Type(s)

Grant

Funding Activity Categories

Health

Eligibility Categories

State Governments
County Governments
City or Township Governments
Special District Governments
Independent School Districts
Public and State Controlled Institutions of Higher Education
Federally Recognized Native American Tribal Governments
Public Housing Authorities or Indian Housing Authorities
Non-Federally Recognized Native American Tribal Organizations
Non-Profits With 501 (c) (3) Status With The IRS (Except Higher Education Institutions)
Non-Profits Without 501 (c) (3) Status With The IRS (Except Higher Education Institutions)
Private Institutions of Higher Education
For-Profit Organizations (Except Small Businesses)
Small Businesses
Other

Other Eligible Applicants include the following: Alaska Native and Native Hawaiian Serving Institutions; Eligible Agencies of the Federal Government; Faith-based or Community-based Organizations; Hispanic-serving Institutions; Historically Black Colleges and Universities (HBCUs); Indian/Native American Tribal Governments (Other than Federally Recognized); Non-domestic (non-U.S.) Entities (Foreign Organizations); Regional Organizations; Tribally Controlled Colleges and Universities (TCCUs) ; U.S. Territory or Possession.

Funding

• Estimated Total Funding:

  $2000000

• Award Range:

  $None - $250000

Grant Description

Purpose. This Funding Opportunity Announcement (FOA) issued by the National Institute on Alcohol Abuse and Alcoholism, National Institutes of Health, solicits Research Project Grant (R01) applications to study molecular and cellular mechanisms of alcohol-induced organ damage. Excessive alcohol consumption can damage all organ systems including the liver, heart, pancreas, lung, endocrine and immune systems, as well as bone and skeletal muscles. The mechanisms for these alcohol-induced tissue injuries are currently not fully understood. NIAAA is especially interested in integrative research that elucidates complex mechanisms of injury either common or unique to each organ system. This FOA also encourages the study of alcohols effect on stem cell, embryonic development, and regeneration. A better understanding of these underlying mechanisms may provide new avenues for developing more effective and novel interventions for prognosis, diagnosis, and treatment of alcohol-induced organ damage. This FOA also aims to foster the utilization of innovative experimental design and emerging technologies, such as functional genomics, systems biology, as well as novel microscopic imaging techniques, to generate new mechanistic and clinical insights into alcohol-induced tissue injuries. Use and development of animal and culture cell models are integral to this effort and encouraged along with studies involving human subjects.

Contact Information

• Agency

  Department of Health and Human Services

• Office:

  National Institutes of Health

• Agency Contact:

  NIH OER Webmaster
  FBOWebmaster@OD.NIH.GOV
  

• Agency Mailing Address:

  If you have any problems linking to this funding announcement, please contact the NIH OER Webmaster

• Agency Email Address:

  FBOWebmaster@OD.NIH.GOV

• More Information:

  http://grants.nih.gov/grants/guide/rfa-files/RFA-AA-09-006.html