Role of the Microflora in the Etiology of Gastro-Intestinal Cancer (R01)

Post Date

June 3rd 2014

Application Due Date

March 3rd 2017

Funding Opportunity Number

PAR-14-242

CFDA Number(s)

93.273
93.393
93.396

Funding Instrument Type(s)

Grant

Funding Activity Categories

Education
Health

Eligibility Categories

State Governments
County Governments
City or Township Governments
Special District Governments
Independent School Districts
Public and State Controlled Institutions of Higher Education
Federally Recognized Native American Tribal Governments
Public Housing Authorities or Indian Housing Authorities
Non-Federally Recognized Native American Tribal Organizations
Non-Profits With 501 (c) (3) Status With The IRS (Except Higher Education Institutions)
Non-Profits Without 501 (c) (3) Status With The IRS (Except Higher Education Institutions)
Private Institutions of Higher Education
For-Profit Organizations (Except Small Businesses)
Small Businesses
Other

Other Eligible Applicants include the following: Alaska Native and Native Hawaiian Serving Institutions; Asian American Native American Pacific Islander Serving Institutions (AANAPISISs); Eligible Agencies of the Federal Government; Faith-based or Community-based Organizations; Hispanic-serving Institutions; Historically Black Colleges and Universities (HBCUs); Indian/Native American Tribal Governments (Other than Federally Recognized); Non-domestic (non-U.S.) Entities (Foreign Organizations); Regional Organizations; Tribally Controlled Colleges and Universities (TCCUs) ; U.S. Territory or Possession.

Funding

• Award Range:

  $None - $None

Grant Description

This Funding Opportunity Announcement (FOA) encourages innovative multidisciplinary research projects that will advance our mechanistic understanding of microflora influences on Gastro-Intestinal (GI) carcinogenesis. Recent advances in our knowledge of GI microflora composition and function have generated a flood of new information, technologies, and capabilities that may for the first time allow mechanistic investigations of very complex, networked host/microbiome interactions on a systems wide scale.This FOA encourages investigators to ingrate this new information into hypothesis-driven studies that can define and validate molecular mechanisms that determine microbe-induced carcinogenic outcomes.Applicants may integrate information from existing large data sets, including metagenomic data sets,or may also propose to generate appropriate new data sets, including but not limited to analysis of host and microbial genomes, proteomes, metabalomes, post-translational modifications, secreted signals, and protein-protein interaction data. An additional goal of this program is to encourage collaborative efforts between scientists currently engaged in GI cancer research with those in scientific disciplines that may not otherwise apply their expertise to study cancer etiology and prevention. Investigators particularly from the disciplines of microbiology, microbial ecology, molecular biology, immunology, nutrition sciences, bioinformatics, and computational sciences are encouraged to apply. A value added from stimulating integrated, multidisciplinary experimental approaches may include the discovery of emergent properties of the GI ecosystem that could not be elucidated using either descriptive bioinformatics or molecular studies alone.

Contact Information

• Agency

  Department of Health and Human Services

• Office:

  National Institutes of Health

• Agency Contact:

  NIH OER Webmaster
  FBOWebmaster@OD.NIH.GOV
  

• Agency Mailing Address:

  If you have any problems linking to this funding announcement, please contact the NIH OER Webmaster

• Agency Email Address:

  FBOWebmaster@OD.NIH.GOV

• More Information:

  http://grants.nih.gov/grants/guide/pa-files/PAR-14-242.html