The Role of Microbial Metabolites in Cancer Prevention and Etiology (U01)
Post Date
April 4th 2013
Application Due Date
November 14th 2014
Funding Opportunity Number
PAR-13-159
CFDA Number(s)
93.393
93.396
Funding Instrument Type(s)
Cooperative Agreement
Funding Activity Categories
Eligibility Categories
State Governments
County Governments
City or Township Governments
Special District Governments
Independent School Districts
Public and State Controlled Institutions of Higher Education
Federally Recognized Native American Tribal Governments
Public Housing Authorities or Indian Housing Authorities
Non-Federally Recognized Native American Tribal Organizations
Non-Profits With 501 (c) (3) Status With The IRS (Except Higher Education Institutions)
Non-Profits Without 501 (c) (3) Status With The IRS (Except Higher Education Institutions)
Private Institutions of Higher Education
For-Profit Organizations (Except Small Businesses)
Small Businesses
Other
Other Eligible Applicants include the following: Alaska Native and Native Hawaiian Serving Institutions; Asian American Native American Pacific Islander Serving Institutions (AANAPISISs); Eligible Agencies of the Federal Government; Faith-based or Community-based Organizations; Hispanic-serving Institutions; Historically Black Colleges and Universities (HBCUs); Indian/Native American Tribal Governments (Other than Federally Recognized); Non-domestic (non-U.S.) Entities (Foreign Organizations); Regional Organizations; Tribally Controlled Colleges and Universities (TCCUs) ; U.S. Territory or Possession; Non-domestic (non-U.S.) Entities (Foreign Institutions) are eligible to apply. Non-domestic (non-U.S.) components of U.S. Organizations are eligible to apply. Foreign components, as defined in the NIH Grants Policy Statement, are allowed.
Funding
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Award Range:
$None - $None
Grant Description
This Funding Opportunity Announcement (FOA) encourages preclinical and clinical research that will describe the effect of microbially generated metabolites in cancer prevention/ progression and the molecular mechanisms underlying these effects: proliferative/apoptotic responses, cytokine production, inflammatory and immunomodulatory effects locally and/or distant. This FOA encourages pre-clinical and clinical studies that will describe the variability in the bacterial metabolites production and their contribution to cancer prevention/promotion among various racial and ethnic groups. Due to inconsistent responses to dietary interventions, this research is necessary to identify who might benefit from specific dietary recommend ations and who might be placed at risk. It is important to identify the factors that contribute to differences in response to foods and food components and to identify early markers that will identify those who will receive maximum benefits from dietary change. As these are complex questions this program will facilitate interdisciplinary collaborations among scientists engaged in research in cancer prevention and microbiology, nutrition, cancer cell biology, and cancer disparities. To achieve this goal all applications are encouraged to include multiple Program Director(s)/Principal Investigator(s) with expertise in cancer biology, microbiology, nutrition, analytical chemistry or genetics. Investigations may use either clinical or preclinical approaches. All awardees are expected to attend an annual meeting with NIH personnel to report new findings and coordinate the exchange of new information and methodologies with interested colleagues and to promote collaboration.
Contact Information
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Agency
Department of Health and Human Services
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Office:
National Institutes of Health
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Agency Contact:
NIH OER Webmaster
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