Vulnerable Dendrites and Synapses in Aging and Alzheimers Disease (R01)

Post Date

December 19th 2008

Application Due Date

January 7th 2012

Funding Opportunity Number

PA-09-061

CFDA Number(s)

93.866

Funding Instrument Type(s)

Grant

Funding Activity Categories

Health

Eligibility Categories

State Governments
County Governments
City or Township Governments
Special District Governments
Independent School Districts
Public and State Controlled Institutions of Higher Education
Federally Recognized Native American Tribal Governments
Public Housing Authorities or Indian Housing Authorities
Non-Federally Recognized Native American Tribal Organizations
Non-Profits With 501 (c) (3) Status With The IRS (Except Higher Education Institutions)
Non-Profits Without 501 (c) (3) Status With The IRS (Except Higher Education Institutions)
Private Institutions of Higher Education
For-Profit Organizations (Except Small Businesses)
Small Businesses
Other

Other Eligible Applicants include the following: Alaska Native and Native Hawaiian Serving Institutions; Eligible Agencies of the Federal Government; Faith-based or Community-based Organizations; Hispanic-serving Institutions; Historically Black Colleges and Universities (HBCUs); Indian/Native American Tribal Governments (Other than Federally Recognized); Non-domestic (non-U.S.) Entities (Foreign Organizations); Regional Organizations; Tribally Controlled Colleges and Universities (TCCUs) ; U.S. Territory or Possession.

Funding

• Award Range:

  $None - $None

Grant Description

Purpose. This FOA issued by the National Institute on Aging (NIA) invites applications for the study of factors regulating neuroplasticity with a particular emphasis on the age-dependent changes in the functions of dendrites, spines and synapses of key cell types in regions of brain especially vulnerable in Alzheimers disease (AD), and in models (in vitro and in vivo) of aging and of AD.Neuroplasticity refers to the changes in both structure and function of the brain that occur in response to experiential stimuli.This ability of the brain to reorganize itself is critical both in normal development and learning, and it is no less important in aging and neurodegenerative disorders. The decline of cognitive functions in aging and disease, especially those functions that rely upon the medial temporal lobe and prefrontal cortex, appears to stem, at least in part, from selective changes in synaptic function and integrity.This initiative solicits research to investigate the factors regulating synaptic plasticity and dysfunction and selective neuronal vulnerability with aging and in certain neurodegenerative disorders such as AD using in vitro and in vivo models. Mechanism of Support. This FOA will utilize the R01 grant mechanism. Funds Available and Anticipated Number of Awards.Awards issued under this FOA are contingent upon the availability of funds and the submission of a meritorious application. Budget and Project Period. The total project period for an application submitted in response to this funding opportunity may not exceed 5 years. Applicants for an R01 award are not limited in dollars but need to reflect the actual needs of the proposed project. Application Research Plan Component Length: The R01 application Research Plan component of the PHS398 (Items 2-5) may not exceed 25 pages, including tables, graphs, figures, diagrams, and charts (see also http://grants.nih.gov/grants/funding/funding_program.htm). Eligible Institutions/Organizations. Institutions/organizations listed in Section III, 1.A. are eligible to apply. Eligible Project Directors/Principal Investigators (PDs/PIs). Includes individuals with the skills, knowledge, and resources necessary to carry out the proposed research are invited to work with their institution/organization to develop an application for support. Individuals from underrepresented racial and ethnic groups as well as individuals with disabilities are always encouraged to apply for NIH support. Number of PDs/PIs. More than one PD/PI (i.e., multiple PDs/PIs), may be designated on the application. Number of Applications. Applicants may submit more than one application, provided that each application is scientifically distinct. Resubmissions.Applicants may submit a resubmission application, but such application must include an Introduction addressing the previous peer review critique (Summary Statement). See new NIH policy on resubmission (amended) applications (NOT-OD-09-003, NOT-OD-09-016). Renewals. Applicants may submit a renewal application.

Contact Information

• Agency

  Department of Health and Human Services

• Office:

  National Institutes of Health

• Agency Contact:

  NIH OER Webmaster
  FBOWebmaster@OD.NIH.GOV
  

• Agency Mailing Address:

  If you have any problems linking to this funding announcement, please contact the NIH OER Webmaster

• Agency Email Address:

  FBOWebmaster@OD.NIH.GOV

• More Information:

  http://grants.nih.gov/grants/guide/pa-files/PA-09-061.html