Mechanisms of Functional Recovery After Stroke (R21)

Post Date

March 5th 2008

Application Due Date

May 7th 2011

Funding Opportunity Number

PA-08-100

CFDA Number(s)

93.173
93.853
93.865
93.866

Funding Instrument Type(s)

Grant

Funding Activity Categories

Health
Income Security and Social Services

Eligibility Categories

State Governments
County Governments
City or Township Governments
Special District Governments
Independent School Districts
Public and State Controlled Institutions of Higher Education
Federally Recognized Native American Tribal Governments
Public Housing Authorities or Indian Housing Authorities
Non-Federally Recognized Native American Tribal Organizations
Non-Profits With 501 (c) (3) Status With The IRS (Except Higher Education Institutions)
Non-Profits Without 501 (c) (3) Status With The IRS (Except Higher Education Institutions)
Private Institutions of Higher Education
For-Profit Organizations (Except Small Businesses)
Small Businesses
Other

Foreign institutions are eligible to apply. Eligible agencies of the Federal Government can apply. Faith-based or community-based organizations can apply.

Funding

• Award Range:

  $None - $200000

Grant Description

Purpose. This Funding Opportunity Announcement (FOA) issued by the National Institute of Neurological Disorders and Stroke (NIINDS), Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD), National Institute on Aging (NIA), and National Institute on Deafness and Other Communication Disorders (NIDCD), National Institutes of Health (NIH), solicits Exploratory/Developmental Grant (R21) applications from institutions/ organizations that propose to find brain mechanisms to improve and develop new approaches to functional recovery after stroke. While stroke is the third leading cause of death in the United States, it is the leading cause of long-term disability in the American population. The Stroke Progress Review Group in 2006 identified the problem of brain repair and rehabilitation after stroke as a major priority for stroke research. In the last decade the major research efforts were directed toward treatment of the acute stroke: reestablishing perfusion of the affected areas, and minimizing the neuronal damage. With the advance of acute stroke treatment, the issues of functional restoration and post-stroke rehabilitation have become increasingly important. At the same time, our understanding of brain responses to stroke-induced damage, brain repair and functional recovery remains relatively poor. Post-stroke rehabilitation is a significant component of stroke treatment in the clinic. Nonetheless, most rehabilitation practices are empirical, rely on behavioral approaches, and are not based on data from large-scale randomized, controlled clinical trials. Relatively little research has been done on the mechanisms of brain repair and plasticity and their relation to behavioral and functional recovery, which are crucial for patients with lifetime consequences of this catastrophic event. This FOA seeks to expand studies on basic brain mechanisms of repair and plasticity after stroke, and on factors that influence these mechanisms. In addition, methods and approaches to improve and enhance reparative processes may be investigated, toward the goal of optimizing and developing promising new approaches to rehabilitation and functional recovery after stroke.

Contact Information

• Agency

  Department of Health and Human Services

• Office:

  National Institutes of Health

• Agency Contact:

  NIH OER Webmaster
  FBOWebmaster@OD.NIH.GOV
  

• Agency Mailing Address:

  If you have any problems linking to this funding announcement, please contact the NIH OER Webmaster

• Agency Email Address:

  FBOWebmaster@OD.NIH.GOV

• More Information:

  http://grants.nih.gov/grants/guide/pa-files/PA-08-100.html