Molecular Mechanisms of Development and Reversal of Alcohol-Induced Liver Fibrosis (R21)

Post Date

April 19th 2007

Application Due Date

November 30th -0001

Multiple Receipt Dates - See Link to Full Announcement for details.

Funding Opportunity Number

PA-07-361

CFDA Number(s)

93.273

Funding Instrument Type(s)

Grant

Funding Activity Categories

Health

Eligibility Categories

State Governments
Public and State Controlled Institutions of Higher Education
Non-Profits With 501 (c) (3) Status With The IRS (Except Higher Education Institutions)
Non-Profits Without 501 (c) (3) Status With The IRS (Except Higher Education Institutions)
Private Institutions of Higher Education
For-Profit Organizations (Except Small Businesses)
Small Businesses
Other

Foreign institutions are eligible to apply.

Funding

• Award Range:

  $None - $None

Grant Description

-Purpose. This Funding Opportunity Announcement (FOA) issued by National Institute on Alcohol Abuse and Alcoholism, National Institutes of Health, solicits Research Grant (R21) applications from institutions/organizations that propose to investigate the underlying molecular mechanisms of the development as well as reversal of alcohol-induced liver fibrosis. Liver fibrosis comprises excessive deposition of extracellular matrix (ECM) components, especially collagen, and activation of hepatic stellate cells (HSCs) is the primary event that triggers the process of fibrogenesis. Understanding the mechanisms of alcohol-induced liver fibrosis is important for the development of strategies for prevention and treatment of this condition. This FOA encourages applicants to test small molecules that reverse or prevent alcohol-induced liver fibrosis. -Mechanism of Support. This FOA will utilize the NIH Research Project Grant (R21) award mechanism and runs in parallel with an FOA of identical scientific scope, PA-07-360 that solicits applications under the R01 mechanism. -Funds Available and Anticipated Number of Awards. Because the nature and scope of the proposed research will vary from application to application, it is anticipated that the size and duration of each award will also vary. The total amount awarded and the number of awards will depend upon the mechanism numbers, quality, duration, and costs of the applications received.

Contact Information

• Agency

  Department of Health and Human Services

• Office:

  National Institutes of Health

• Agency Contact:

  NIH OER Webmaster
  FBOWebmaster@OD.NIH.GOV
  

• Agency Mailing Address:

  If you have any problems linking to this funding announcement, please contact the NIH OER Webmaster

• Agency Email Address:

  FBOWebmaster@OD.NIH.GOV

• More Information:

  http://grants.nih.gov/grants/guide/pa-files/PA-07-361.html