Controlling Cellular Machinery - Diagnostics and Therapeutics

Post Date

November 29th 2010

Application Due Date

March 3rd 2011

Funding Opportunity Number

DARPA-BAA-11-23

CFDA Number(s)

12.910

Funding Instrument Type(s)

Cooperative Agreement

Funding Activity Categories

Science and Technology and other Research and Development

Eligibility Categories

Unrestricted

Funding

• Award Range:

  $None - $None

Grant Description

DARPA is soliciting research proposals for the development of synthetic regulatory genetic elements that can be used in mammalian cells. The proposed research should comprise approaches that enable fundamental advances to the development and broad application of synthetic regulatory elements for in vivo biomedical applications to detect, treat, or prevent disease. Technical challenges that need to be addressed include, but are not limited to, discovery, characterization, evolution or design, and demonstration of orthogonal and modular genetic regulatory elements; construct stability and function in the cell; and synthesis, amplification, and delivery of novel circuits in mammalian cells. The designed modules must limit specific interactions with the cellular metabolism or milieu to the desired performance characteristics and demonstrate maintenance of independent function without interference long enough to achieve the intended clinical effect. Specifically excluded is research that primarily results in evolutionary improvements to the existing state of practice. Proposers that intend to pursue nucleic acid vaccines as an application are referred to the companion announcement, Controlling Cellular Machinery - Vaccines, DARPA-BAA-11-22.

Contact Information

• Agency

  Department of Defense

• Office:

  Defense Advanced Research Projects Agency

• Agency Contact:

  Dr. Daniel Wattendorf

• Agency Mailing Address:

  BAA Coordinator

• Agency Email Address:

  DARPA-BAA-11-23@darpa.mil

• Location:

  DARPA - Defense Sciences Office